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Research paper

Folic acid supplementation during pregnancy for maternal health and pregnancy outcomes.

The Cochrane database of systematic reviews
Q1
Mar 2013
Citations: 228
Influential: 9
Systematic Reviews / Meta-Analyses
93

Study answer

What this study found

BACKGROUND During pregnancy, fetal growth causes an increase in the total number of rapidly dividing cells, which leads to increased requirements for folate. Inadequate folate intake leads to a decrease in serum folate concentration, resulting in a decrease in erythrocyte folate concentration, a rise in homocysteine concentration, and megaloblastic changes in the bone marrow and other tissues with rapidly dividing cells OBJECTIVES To assess the effectiveness of oral folic acid supplementation alone or with other micronutrients versus no folic acid (placebo or same micronutrients but no folic…

A separate results summary is not available, so this answer uses the paper abstract.

Study & population
Systematic Reviews / Meta-Analyses

Original abstract

BACKGROUND During pregnancy, fetal growth causes an increase in the total number of rapidly dividing cells, which leads to increased requirements for folate. Inadequate folate intake leads to a decrease in serum folate concentration, resulting in a d…