Research paper
Estimation of the dietary requirement for vitamin D in white children aged 4-8 y: a randomized, controlled, dose-response trial.
Study answer
What this study found
Vitamin D3 supplementation increased winter serum 25(OH)D in a clear dose-response manner and lowered PTH, with no safety signal. Endpoint serum 25(OH)D was 31.1 ± 7.5 nmol/L with placebo, 61.8 ± 10.6 nmol/L with 10 mg/day, and 75.8 ± 11.5 nmol/L with 20 mg/day (p<0.0001). Endpoint plasma PTH was 2.52 ± 1.23 pmol/L with placebo, 2.20 ± 0.73 pmol/L with 10 mg/day, and 1.91 ± 0.85 pmol/L with 20 mg/day (p<0.0001). Serum calcium did not differ meaningfully between groups at endpoint (p=0.45), and no serious adverse events or supplementation-related adverse events were reported. The authors…
- Study & population
- Randomized, double-blind, placebo-controlled dose-response trial in healthy white Danish or European children aged 4 to 8 years living at northern latitude in Denmark during winter.
- Intervention
- Vitamin D3 (Minisun tablets) was given orally once daily for 20 weeks at 10 mg/day or 20 mg/day in a randomized, double-blind, placebo-controlled dose-response trial.
- Key limitation
- Arm-specific sample sizes and detailed arm-level demographics were not reported in the extraction.
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Open PDFOriginal abstract
BACKGROUND Children in northern latitudes are at high risk of vitamin D deficiency during winter because of negligible dermal vitamin D3 production. However, to our knowledge, the dietary requirement for maintaining the nutritional adequacy of vitami…