Research paper
Enteral nutrition formulations for acute pancreatitis.
Study answer
What this study found
Overall, there was no firm evidence supporting one enteral nutrition formulation over another in acute pancreatitis, and the evidence was low to very low quality for most outcomes. Immunonutrition reduced all-cause mortality in pooled analysis, RR 0.49 (0.29 to 0.80), while probiotics showed no mortality benefit overall, RR 1.13 (0.66 to 1.91), and raised safety concerns because bowel ischaemia was increased in the Besselink 2008 trial, RR 17.89 (1.05 to 304.59). Fibre-enriched formulas showed possible benefit in small datasets, including shorter hospital stay, MD -9.28 ( -13.21 to -5.35 ),…
- Study & population
- Systematic review and meta-analysis of randomized trials in hospitalized adults with acute pancreatitis, including mild to severe disease and different etiologies.
- Intervention
- This systematic review evaluated several enteral nutrition formulations used in acute pancreatitis, including immunonutrition, probiotic-enriched formulas, fibre-enriched formulas, semi-elemental formulas, and enteral nutrition versus no intervention or other formulas.
- Key limitation
- The evidence base was small, heterogeneous, and largely low to very low quality, with different formulations, comparators, doses, and outcome definitions across trials.
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Open PDFOriginal abstract
BACKGROUND Acute pancreatitis is a common and potentially lethal disease with increasing incidence. Severe cases are characterised by high mortality, and despite improvements in intensive care management, no specific treatment relevantly improves cli…