Research paper
Efficacy of Probiotics Supplementation On Chronic Kidney Disease: a Systematic Review and Meta-Analysis
Study answer
What this study found
Probiotics modestly improved the uremic toxin p-cresyl sulfate, but did not improve kidney function, blood urea nitrogen, hemoglobin, or C-reactive protein. For p-cresyl sulfate, 3 studies contributed data (N_probiotics=65; N_placebo=60) and the pooled effect favored probiotics (SMD -0.57, 95% CI -0.99 to -0.14; P=0.01; I2 = 25%). For IL-6, 3 studies (N_probiotics=134) showed a significant increase (P=0.03; 95% CI 0.03 to 0.72; I2 = 0%). Serum creatinine (P = 0.47; 95% CI -0.13 to 0.28), BUN (P = 0.73; 95% CI -9.26 to 6.50), Hb (P = 0.49), and CRP (P = 0.49; 95% CI -6.45 to 3.11; I2 = 28%)…
- Study & population
- Systematic review and meta-analysis of 8 randomized controlled trials in adults with chronic kidney disease stages 3 to 5, including both non-dialysis patients and patients receiving hemodialysis or peritoneal dialysis.
- Intervention
- Oral probiotic supplementation was tested in multiple formulations, mainly multi-strain Lactobacillus and Bifidobacterium products, sometimes with Streptococcus thermophilus.
- Key limitation
- The evidence base was small, with only 8 trials and limited participants contributing to each outcome.
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Open PDFOriginal abstract
Background/Aims: Dysbiosis of the intestinal microbiota may accelerate the progression of chronic kidney disease (CKD) by increasing the levels of urea toxins. In recent years, probiotics have been recognized to maintain the physiological balance of …