Research paper
Efficacy of Bifidobacterium animalis subsp. lactis BL-99 in the treatment of functional dyspepsia: a randomized placebo-controlled clinical trial
Study answer
What this study found
High-dose BL-99 improved functional dyspepsia symptoms more than placebo and the proton pump inhibitor after 8 weeks, and the benefit persisted for 2 weeks after treatment stopped. The 8-week complete response rate for FD score was 90.0% with BL-99_high versus 58.0% with placebo, 74.0% with BL-99_low, and 70.0% with positive control (p = 0.001, p = 0.044, and p = 0.017, respectively). At 2-week follow-up, the complete response rate remained higher with BL-99_high (84.0%) than placebo (62.0%) and positive control (66.0%) (p = 0.016 and p = 0.041). Serum gastrin G17 increased more with…
- Study & population
- Randomized, placebo-controlled trial in adults 18-60 years with functional dyspepsia diagnosed by Rome IV criteria and no organic lesions on recent upper endoscopy.
- Intervention
- Bifidobacterium animalis subsp.
- Key limitation
- The trial was short, with follow-up limited to 2 weeks after stopping treatment, and the overview notes that benefit did not persist at 8 weeks post-treatment.
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Open PDFOriginal abstract
Functional dyspepsia (FD) is a common chronic gastrointestinal disorder. Here, in a randomized, parallel-group, positive-drug, and placebo-controlled clinical trial, the authors show that supplementation with the probiotic Bifidobacterium animalis su…