Efficacy and Safety of Resveratrol Supplements on Blood Lipid and Blood Glucose Control in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Evidence-based Complementary and Alternative Medicine : eCAM
Aug 2021
Citations:18
Influential Citations:1
Systematic Reviews / Meta-Analyses
84
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Methods
Adults with type 2 diabetes mellitus; 15 randomized controlled trials comprising 896 participants; mixed genders; mean ages generally in the 50s–60s; multicountry settings (e.g., Iran, China, Japan, Hungary, Egypt, India, Singapore).
Intervention
Oral resveratrol supplements in capsule form; regimens varied by trial (examples include 100 mg/day, 240 mg BID, 400–500 mg/day, 240 mg BID, 400 mg BID, 500 mg BID, and up to 3000 mg/day in one trial); durations ranged from 1 month to 6 months.
Results
Resveratrol supplementation may improve insulin resistance and glycemic control in adults with type 2 diabetes: HOMA-IR reduced by 0.99 (95% CI −1.61 to −0.38; P = 0.002); HbA1c reduced by 0.45 percentage points (95% CI −0.73 to −0.16; P = 0.002); fasting glucose reduced by 19.61 mg/dL (95% CI −26.02 to −13.20; P < 0.00001); fasting insulin reduced (SMD −0.67; 95% CI −1.21 to −0.14; P = 0.01). No significant changes in TC (−7.11; 95% CI −16.28 to 2.06; P = 0.13), TG (−2.15; 95% CI −5.52 to 1.22; P = 0.21), or LDL-C (−6.84; 95% CI −16.60 to 2.92; P = 0.17). Adverse events did not differ significantly between groups. Conclusion: Resveratrol could be a potential adjunct for glycemic control in type 2 diabetes, but findings are limited by substantial heterogeneity and small trial sizes; more high-quality randomized trials are needed to confirm efficacy and safety.
Limitations
High heterogeneity across trials (I2 up to 95% for several outcomes); small sample sizes in many RCTs; wide variation in resveratrol dose, formulation, and duration; several studies with unclear randomization or blinding; incomplete outcome data in some trials; safety data limited.

Abstract

Background Diabetes is a major public health concern. Resveratrol has shown great beneficial effects on hyperglycemia and insulin resistance and as an antioxidant. Methods We searched the Chinese and English databases (such as CNKI, PubMed, and Embas...