Research paper
Effects of vitamin D supplementation on depression and some selected pro-inflammatory biomarkers: a double-blind randomized clinical trial
Study answer
What this study found
Vitamin D3 supplementation improved depressive symptoms and raised circulating 25(OH)D, but it did not meaningfully change the selected inflammatory biomarkers. In the intervention arm, 25(OH)D increased by 40.83 ± 28.57 nmol/L versus 5.14 ± 23.44 nmol/L in control (P < 0.001), and BDI-II scores decreased by 11.75 ± 6.40 versus 3.61 ± 10.40 in control (P = 0.003). IL-1β, IL-6, and hs-CRP showed no significant within- or between-group differences. Final iPTH did not differ significantly between groups, although the control group showed a within-group increase of 5.10 ± 6.002 pg/mL (P < 0.001).
- Study & population
- Double-blind randomized clinical trial conducted in adults with mild to moderate depression recruited from outpatient clinics of Baharloo Hospital in Tehran, Iran.
- Intervention
- Oral vitamin D3 (cholecalciferol) was given at 50,000 IU every 2 weeks for 8 weeks.
- Key limitation
- The active intervention arm was small, and the treatment period was short at 8 weeks.
View source
Open PDFOriginal abstract
Background Both augmented inflammatory reaction and low vitamin D status are associated with depression but the magnitude of their relationships is unclear. This study was, therefore, conducted to evaluate the effects of vitamin D supplementation on …