Effects of vitamin D supplementation on metabolic and endocrine parameters in PCOS: a randomized-controlled trial

Study answer

What this study found

Vitamin D supplementation did not significantly improve the primary metabolic outcome overall, but it did lower plasma glucose at 60 minutes during the oral glucose tolerance test. The adjusted treatment effect for plasma glucose area under the curve at 24 weeks was -9.19 (-21.40 to 3.02; p = 0.139), while 60-minute glucose decreased by -10.2 mg/dL (95% CI -20.2 to -0.3; p = 0.045). Vitamin D status and related endocrine markers improved: 25(OH)D increased by 33.4 nmol/L (95% CI 24.5 to 42.2; p < 0.001), PTH decreased by -6.6 (p = 0.004), and 1,25(OH)2D increased by 27 (p = 0.006). In women…

Study & population

Randomized controlled trial in premenopausal women with polycystic ovary syndrome and vitamin D insufficiency (25[OH]D <75 nmol/L).

Intervention

Women in the active arm received cholecalciferol 20,000 IU weekly, given as 50 oily drops per week (Oleovit D3-drops), for 24 weeks.

Key limitation

The primary endpoint was not significant overall, and several findings were secondary or subgroup analyses.

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Original abstract