Effects of vitamin D supplementation on glucose metabolism, lipid concentrations, inflammation, and oxidative stress in gestational diabetes: a double-blind randomized controlled clinical trial.

Study answer

What this study found

Vitamin D supplementation improved glycemic status and lowered total cholesterol and LDL cholesterol, but did not improve triglycerides, HDL cholesterol, inflammation, or oxidative stress markers. Compared with placebo, the vitamin D group had greater increases in 25(OH)D (+18.5 6 20.4 ng/mL vs +0.5 6 6.1 ng/mL; P < 0.001), greater reductions in fasting plasma glucose (−17.1 6 14.8 mg/dL vs −0.9 6 16.6 mg/dL; P < 0.001), insulin (−3.08 6 6.62 mIU/mL vs +1.34 6 6.51 mIU/mL; P = 0.01), HOMA-IR (−1.28 6 1.41 vs +0.34 6 1.79; P < 0.001), total cholesterol (−11.0 6 23.5 mg/dL vs +9.5 6 36.5…

Study & population

Randomized, double-blind, placebo-controlled clinical trial in pregnant women with gestational diabetes mellitus in Kashan, Iran.

Intervention

Vitamin D3 (cholecalciferol) was given as 50,000 IU oral capsules, with two administrations during the 6-week trial, at baseline and on day 21.

Key limitation

The intervention period was short at 6 weeks and the active-arm sample was small, limiting precision and longer-term inference.

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Original abstract