Effects of Vitamin D on Blood Pressure and Cardiovascular Risk Factors: A Randomized Controlled Trial

Study answer

What this study found

Vitamin D3 did not lower 24-hour blood pressure or improve most cardiovascular risk markers in hypertensive adults with low vitamin D status. For 24-hour systolic BP, the treatment effect was -0.4 mmHg (95% CI -2.8 to 1.9; P = 0.712), and for 24-hour diastolic BP it was 0.2 mmHg (95% CI -1.3 to 1.7; P = 0.751). Vitamin D3 did raise 25-hydroxyvitamin D from 22.0±5.5 to 36.2±7.3 ng/mL (treatment effect 11.5; 95% CI 9.4 to 13.7; P < 0.001) and lowered parathyroid hormone (treatment effect -5.7 pg/mL; 95% CI -9.3 to -2.1; P = 0.003). No meaningful changes were seen in NT-proBNP, corrected QT…

Study & population

Single-center randomized controlled trial conducted at the Medical University of Graz, Austria, in adults with arterial hypertension and low 25-hydroxyvitamin D levels (<30 ng/mL).

Intervention

Oral vitamin D3 was given as oily drops at 2800 IU/day (7 drops daily) for 8 weeks.

Key limitation

The intervention was short duration (8 weeks) and single-center, which limits assessment of longer-term cardiovascular outcomes.

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Original abstract