Research paper
Effects of Probiotics in Preterm Infants: A Network Meta-analysis
Study answer
What this study found
Synbiotic regimens outperform single-strain probiotics for key outcomes in preterm infants. Bifidobacterium + Lactobacillus vs placebo: mortality RR 0.56 (95% credible interval 0.34-0.84); NEC RR 0.47 (0.27-0.79). Lactobacillus + Prebiotic vs placebo: NEC morbidity RR 0.06 (0.01-0.41); sepsis morbidity RR 0.18 (0.07-0.53). Bifidobacterium + Prebiotic had highest probability of lowest mortality (SUCRA 83.94%); Lactobacillus + Prebiotic had highest probability of the lowest NEC (SUCRA 95.62%). For secondary outcomes, Lactobacillus + Prebiotic ranked highest for time to full enteral feeding…
- Study & population
- Design: Bayesian network meta-analysis of randomized controlled trials evaluating probiotic supplementation in preterm infants.
- Key limitation
- Data for extremely low birth weight or gestational age were underreported in some trials.
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Open PDFOriginal abstract
Probiotics have proven to be effective in promoting premature infants’ health, but the optimal usage is unknown. CONTEXT: Probiotics have proven to be effective in promoting premature infants’ health, but the optimal usage is unknown. OBJECTIVE: To c…