Research paper

Effects of Perioperative Probiotics and Synbiotics on Pancreaticoduodenectomy Patients: A Meta-Analysis of Randomized Controlled Trials

Frontiers in Nutrition

Aug 2021

DOI: 10.3389/fnut.2021.715788

Citations: 14

Influential: 1

Systematic Reviews / Meta-Analyses

Study answer

What this study found

Probiotic or synbiotic supplementation did not reduce perioperative mortality but significantly reduced postoperative infection rates, delayed gastric emptying, hospital stay length, and antibiotic usage durations. These findings suggest potential clinical benefits of probiotics and synbiotics in improving recovery after pancreaticoduodenectomy.

Study & population: Six randomized controlled trials (RCTs) involving 294 participants were analyzed.
Intervention: Evaluation of probiotics and synbiotics during pancreaticoduodenectomy to assess their efficacy in preventing postoperative infections and improving surgical outcomes.
Key limitation: Limited number of studies and participants; varied types of probiotics and synbiotics used; concerns about potential bias due to lack of double-blinding in some studies.

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Original abstract

Post-pancreaticoduodenectomy infections cause mortality, morbidity, and prolonged antibiotic use. Probiotics or synbiotics may be advantageous for preventing postoperative infections, but their benefits on pancreaticoduodenectomy outcomes are controv…