Effects of Omega-3 Fatty Acids Supplementation on Serum Lipid Profile and Blood Pressure in Patients with Metabolic Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Study answer

What this study found

Omega-3 PUFA supplementation reduced triglycerides and lowered both systolic and diastolic blood pressure, but it did not significantly change total cholesterol, LDL-C, or HDL-C. Pooled effects favored supplementation for triglycerides (SMD = −0.39; 95% CI: −0.59 to −0.18; I2 = 17.2%), systolic blood pressure (SMD = −0.54; 95% CI: −0.86 to −0.22; I2 = 48.6%), and diastolic blood pressure (SMD = −0.56; 95% CI: −0.79 to −0.33; I2 = 14.0%). No significant effects were seen for total cholesterol (SMD = −0.02; 95% CI: −0.22 to 0.18), LDL-C (SMD = 0.18; 95% CI: −0.18 to 0.53), or HDL-C (SMD =…

Study & population

Systematic review and meta-analysis of randomized controlled trials in adults with metabolic syndrome from multiple countries.

Intervention

Oral omega-3 PUFA supplementation was evaluated across randomized trials, using fish oil, flaxseed oil, or n-3 PUFA formulations.

Key limitation

The evidence base was relatively small and included heterogeneous omega-3 formulations, doses, and treatment durations.

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Original abstract