Research paper

Effects of oleoylethanolamide supplementation on atherogenic indices and hematological parameters in patients with nonalcoholic fatty liver disease: A clinical trial

Health Promotion Perspectives

Nov 2020

DOI: 10.34172/hpp.2020.56

Citations: 15

Influential: 0

Interventional (Human) Studies

Study answer

What this study found

OEA supplementation led to significant improvements in several atherogenic indices, including reduced LDL-C/HDL-C, TG/HDL-C, and non-HDL-C/HDL-C ratios. It also decreased red blood cell distribution width (RDW) compared to the placebo group.

Study & population: Seventy-six obese patients with NAFLD were randomized to receive either 250 mg of OEA or a placebo for 12 weeks, while following a weight loss diet.
Intervention: The trial evaluated the effects of oleoylethanolamide (OEA) supplementation alongside a weight loss intervention in patients with nonalcoholic fatty liver disease (NAFLD).

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Original abstract

Background: Non-alcoholic fatty liver disease (NAFLD) is the most frequent cause of chronic liver disease in the world. The current interventional trial aimed to evaluate the effects of supplementation with oleoylethanolamide (OEA) in combination wit…