Effects of Inulin Propionate Ester Incorporated into Palatable Food Products on Appetite and Resting Energy Expenditure: A Randomised Crossover Study

Study answer

What this study found

Adding inulin-propionate ester to bread rolls and smoothies was well tolerated and did not change palatability, while reducing ad libitum energy intake in the crossover test. The overall treatment effect for intake was significant (p = 0.012); post hoc comparisons showed trends favoring IPE versus control (p = 0.056) and versus inulin (p = 0.059), whereas inulin did not differ from control (p = 0.75). The appetite effect was not explained by peripheral PYY or GLP-1 changes, and the higher resting energy expenditure seen with IPE was not robust after adjustment for fat-free mass (p =…

Study & population

This was a randomized, double-blind, crossover study in healthy overweight or obese adults aged 18 to 65 years with BMI 25 to 40, conducted in London, United Kingdom.

Intervention

In a randomized crossover regimen, participants consumed palatable food products (one bread roll and one fruit smoothie daily) containing inulin-propionate ester (IPE) or inulin as a positive control.

Key limitation

The trial was small, with only 21 completers and 19 participants contributing to the ad libitum intake analysis.

View full study detailsView sourceOpen PDF

Original abstract