Effects of curcumin supplementation on vitamin D levels in women with premenstrual syndrome and dysmenorrhea: a randomized controlled study

Study answer

What this study found

Curcumin improved serum 25-hydroxyvitamin D within the active arm, but the vitamin D benefit was not significant versus placebo overall. In the curcumin group, 25-hydroxyvitamin D increased from 12.8 ng/mL (7.0-24.6) to 16.2 ng/mL (6.4-28.8), P = 0.045; in placebo, it changed from 18.6 ng/mL (2.2-26.8) to 21.3 ng/mL (5.2-27.1), P = 0.17. Vitamin D status improved in 25% of the curcumin group versus 18% of placebo participants, with between-group p = 0.71. Curcumin also reduced AST (P = 0.040) and direct bilirubin (P = 0.021), while fasting blood glucose and lipid profiles were not…

Study & population

Randomized controlled trial in young women aged 18 to 24 years with a history of moderate to severe premenstrual syndrome and dysmenorrhea.

Intervention

The active regimen was one oral capsule daily containing 500 mg curcuminoids (C3 Complex) plus 5 mg piperine (Bioperine) for 10 days per menstrual cycle, starting 7 days before and continuing through 3 days after the estimated onset of menstruation, for 3 menstrual cycles.

Key limitation

The intervention was short, spanning only 3 menstrual cycles, and the analyzed active-arm sample was small.

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Original abstract