Research paper
Effects of Combined Calcium and Vitamin D Supplementation on Insulin Secretion, Insulin Sensitivity and β-Cell Function in Multi-Ethnic Vitamin D-Deficient Adults at Risk for Type 2 Diabetes: A Pilot Randomized, Placebo-Controlled Trial
Study answer
What this study found
Overall, 6 months of calcium plus vitamin D did not improve insulin sensitivity, insulin secretion, or beta-cell function versus placebo in this vitamin D-deficient, diabetes-risk population. For HOMA2%S, the treatment group changed from 63.9 (29.0) at baseline to 61.1 (25.6) at 6 months, while placebo changed from 55.1 (30.4) to 52.5 (27.7); the treatment-by-time interaction was not significant (0.96, 0.10). Matsuda index, insulinogenic index, AUC for C-peptide, and disposition index were also not significantly different between groups. In post hoc analysis among participants with…
- Study & population
- Pilot randomized, placebo-controlled trial in multi-ethnic vitamin D-deficient adults at risk for type 2 diabetes in Melbourne, Australia.
- Intervention
- Participants in the active arm received oral vitamin D3 2,000 IU daily (two OstevitD capsules) plus elemental calcium 1,200 mg daily as calcium carbonate, taken with breakfast for 6 months.
- Key limitation
- This was a small pilot study with only 35 completers in the active arm, limiting power to detect modest effects.
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Open PDFOriginal abstract
Objectives To examine whether combined vitamin D and calcium supplementation improves insulin sensitivity, insulin secretion, β-cell function, inflammation and metabolic markers. Design 6-month randomized, placebo-controlled trial. Participants Ninet…