Research paper

Effects of cis-9,trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese men.

The American journal of clinical nutrition

Aug 2004

DOI: 10.1093/AJCN/80.2.279

Citations: 251

Influential: 19

Interventional (Human) Studies

Study answer

What this study found

Overall, purified c9,t11 CLA had an unfavorable effect on metabolic health in these obese men. Compared with placebo, insulin sensitivity decreased by 15% (P = 0.05), and mean insulin-mediated glucose uptake was also lower with c9,t11 CLA (P = 0.05). Markers of lipid peroxidation increased, including 8-iso-prostaglandin F2alpha by 50% (P = 0.01) and 15-keto-dihydro-prostaglandin F2alpha by 15% (P = 0.05). Lipoproteins, triacylglycerol, and free fatty acids did not differ significantly, but body weight and BMI increased within the c9,t11 CLA group over 12 weeks. No side effects or liver…

Study & population: Randomized, double-blind, placebo-controlled trial in abdominally obese white men at high cardiovascular risk.
Intervention: The active intervention was oral cis-9,trans-11 conjugated linoleic acid (CLA), 3 g/day given as 6 capsules/day for 3 months.
Key limitation: Small trial with only 13 participants in the active arm and 3-month follow-up.

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Original abstract

No abstract is available for this paper.