Research paper
Effects of calcium–vitamin D co-supplementation on glycaemic control, inflammation and oxidative stress in gestational diabetes: a randomised placebo-controlled trial
Citations: 144
Influential: 7
Interventional (Human) Studies
87
Study answer
What this study found
Calcium plus vitamin D co-supplementation improved glycaemic control and several lipid and oxidative stress markers in women with gestational diabetes over 6 weeks. In the active group, 25(OH)D increased by +48.19±46.64 nmol/l (p<0.001), FPG decreased by -0.89±0.69 mmol/l versus +0.26±0.92 in placebo (p<0.001), insulin decreased by -13.55±35.25 pmol/l versus +9.17±38.50 (p=0.02), and HOMA-IR decreased by -0.91±1.18 versus +0.63±2.01 (p=0.001). QUICKI increased by +0.02±0.03 versus -0.002±0.02 (p=0.003), LDL-cholesterol decreased by -0.23±0.79 mmol/l versus +0.26±0.74 (p=0.02),…
- Study & population
- Randomized, placebo-controlled trial in pregnant women with gestational diabetes mellitus treated at maternity clinics affiliated with Kashan University of Medical Sciences, Kashan, Iran.
- Intervention
- Oral calcium carbonate 1,000 mg/day plus vitamin D3 50,000 U twice during the 6-week trial, given at baseline and on day 21.
- Key limitation
- Small single-center trial with only 28 women in the active arm and a 6-week duration, which limits precision and long-term inference.
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