Effect of vitamin E supplementation on HDL function by haptoglobin genotype in type 1 diabetes: results from the HapE randomized crossover pilot trial

What this study found

Vitamin E showed a possible genotype-specific benefit on HDL function, but the overall treatment-by-genotype signal was not statistically significant and the findings require replication. HDL cholesterol efflux worsened with increasing numbers of Hp2 alleles at baseline (p-trend = 0.003), and alpha-tocopherol increased cholesterol efflux in Hp 2-2 carriers (b = 0.79, p = 0.03). However, the genotype-treatment interaction was not significant for cholesterol efflux (p = 0.25) or lipid peroxides (p = 0.63). Vitamin E also increased lipid peroxides in Hp 1 allele carriers (Hp 1-1: b = 0.18, p =…

Study & population

Adults with type 1 diabetes age 30 years or older from Allegheny County, Pennsylvania, were studied in a genotype-stratified crossover design.

Intervention

In this randomized, double-blind, placebo-controlled crossover pilot trial, participants received daily vitamin E as 400 IU d-alpha-tocopherol acetate for 8 weeks, with a matched placebo used in the crossover period.

Key limitation

This was a small pilot study with short 8-week treatment periods, limiting power to detect genotype-specific effects.

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