Effect of vitamin D supplementation on bone and vitamin D status among Pakistani immigrants in Denmark: a randomised double-blinded placebo-controlled intervention study

Study answer

What this study found

Vitamin D3 supplementation at both 10 mg/d and 20 mg/d improved vitamin D status and lowered intact parathyroid hormone, but it did not significantly improve bone turnover markers or bone mass over the study period. Serum 25-hydroxyvitamin D rose by 31-32 nmol/L in women with both doses, by 16.5 nmol/L in men with 10 mg/d, and by 35.8 nmol/L in men with 20 mg/d; levels increased by 6 months and then remained stable. Bone findings were limited: whole-body BMC increased in men with 20 mg/d (ratio 1.01; P=0.049), while women had a small increase in whole-body BA (ratio 1.02; P=0.02) and a…

Study & population

Randomized, double-blind, placebo-controlled intervention study in Pakistani-origin immigrants living in Denmark with low vitamin D status.

Intervention

Participants were randomized to oral vitamin D3 tablets taken daily for 12 months at either 10 mg/d or 20 mg/d, compared with placebo.

Key limitation

The authors note limited sample size and dropout, which reduce power to detect skeletal effects.

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Original abstract