Effect of vitamin D supplementation alone or with calcium on adiposity measures: a systematic review and meta-analysis of randomized controlled trials.

Study answer

What this study found

Vitamin D supplementation, with or without calcium, did not meaningfully reduce adiposity in adults. For vitamin D alone versus placebo, BMI was WMD −0.06 (−0.14 to 0.03), weight was WMD −0.05 (−0.32 to 0.23), and fat mass was WMD −0.43 (−1.69 to 0.84), with p = 0.20. For vitamin D plus calcium versus calcium control, BMI was WMD 0.02 (−0.11 to 0.14), weight was WMD 0.12 (−0.24 to 0.49), and fat mass was WMD 0.12 (−0.22 to 0.45), with p = 0.80. No dose-response relationship was found, and the authors concluded that more adequately powered trials with baseline vitamin D assessment and…

Study & population

Systematic review and meta-analysis of randomized controlled trials in adults aged 18 years and older.

Intervention

Across 26 randomized controlled trials, adults received vitamin D supplementation alone or vitamin D combined with calcium.

Key limitation

The included trials used heterogeneous vitamin D formulations and doses, with varying calcium cointerventions, which limits comparability.

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Original abstract