Effect of Supplementation With High-Selenium Yeast on Plasma Lipids

Study answer

What this study found

Selenium supplementation produced modest, dose-specific improvements in plasma lipids, but the pattern was not uniform and the clinical significance is uncertain. In the 100 mcg/day arm, total cholesterol fell more than placebo by -0.22 mmol/L (95% CI -0.42 to -0.03; P=0.02) and non-HDL cholesterol by -0.20 mmol/L (95% CI -0.37 to -0.04; P=0.02). In the 200 mcg/day arm, total cholesterol decreased by -0.25 mmol/L (95% CI -0.44 to -0.07; P=0.008), non-HDL cholesterol by -0.27 mmol/L (95% CI -0.43 to -0.10; P=0.001), and the total-HDL cholesterol ratio by -0.15 (95% CI -0.26 to -0.03; P=0.02).…

Study & population

Randomized, placebo-controlled trial in older adults in the United Kingdom with relatively low selenium status.

Intervention

Participants received high-selenium yeast (SelenoPrecise, Pharma Nord) or placebo yeast once daily for 6 months.

Key limitation

Effects were modest, dose-specific, and not consistent across all lipid outcomes or selenium doses.

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Original abstract