Research paper
Effect of probiotics at different intervention time on glycemic control in patients with type 2 diabetes mellitus: a systematic review and meta-analysis
Study answer
What this study found
Probiotics were associated with modest improvements in glycemic control in type 2 diabetes, with benefits for HbA1c, insulin, and HOMA-IR, but not fasting blood glucose or BMI. Compared with control, HbA1c decreased by MD = -0.33, 95% CI (-0.59, -0.07), p = 0.01. Insulin also improved, with SMD = -0.48, 95% CI (-0.74, -0.22), p = 0.0003, and HOMA-IR decreased by SMD = -1.36, 95% CI (-2.30, -0.41), p = 0.005. The authors suggested a time-related effect, with HbA1c reduction seen at 6 to 8 weeks and insulin/HOMA-IR improvements seen at both 6 to 8 weeks and 12 to 24 weeks.
- Study & population
- Systematic review and meta-analysis of eight randomized controlled trials in adults with type 2 diabetes mellitus from multiple countries, including Iran, Brazil, Malaysia, Ukraine, and Greece.
- Intervention
- Oral probiotic interventions were tested against placebo or usual care in adults with type 2 diabetes mellitus.
- Key limitation
- The evidence base was small, with only eight RCTs and 507 total participants, limiting certainty.
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Open PDFOriginal abstract
Background Type 2 diabetes mellitus(T2DM) is characterized by hyperglycemia. Gut microbiome adjustment plays a positive part in glucose regulation, which has become a hotspot. Probiotics have been studied for their potential to control the gut flora …