Research paper
Effect of Omega-3 Fatty Acids, Lutein/Zeaxanthin, or Other Nutrient Supplementation on Cognitive Function: The AREDS2 Randomized Clinical Trial.
Study answer
What this study found
Omega-3 LCPUFAs and lutein/zeaxanthin did not improve cognitive function. For omega-3 LCPUFAs versus no omega-3 LCPUFAs, the yearly change in composite cognitive score was -0.19 versus -0.18, with a between-group difference of -0.03 (99% CI, -0.20 to 0.13; P = .63); TICS yearly change was -0.10 (99% CI, -0.24 to 0.04; P = .07), and the odds of TICS score <30 was 1.12 (99% CI, 0.91 to 1.39; P = .15). For lutein/zeaxanthin versus no lutein/zeaxanthin, the yearly composite score change was -0.18 versus -0.19, with a difference of 0.03 (99% CI, -0.14 to 0.19; P = .66); TICS yearly change was…
- Study & population
- Randomized, multicenter ancillary cognitive study in older adults with age-related macular degeneration at 82 US clinical sites.
- Intervention
- This was a 2x2 factorial oral supplementation comparison within AREDS2.
- Key limitation
- The analyzable samples were smaller than the randomized active-arm totals, indicating attrition.
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Open PDFOriginal abstract
IMPORTANCE Observational data have suggested that high dietary intake of saturated fat and low intake of vegetables may be associated with increased risk of Alzheimer disease. OBJECTIVE To test the effects of oral supplementation with nutrients on co…