Research paper

Effect of lutein and antioxidant dietary supplementation on contrast sensitivity in age-related macular disease: a randomized controlled trial

European Journal of Clinical Nutrition

Jan 2007

DOI: 10.1038/sj.ejcn.1602626

Citations: 80

Influential: 1

Interventional (Human) Studies

Study answer

What this study found

Daily lutein and antioxidant supplementation for 9 months did not improve contrast sensitivity in ARM-affected eyes compared with placebo. Baseline contrast sensitivity was similar between groups, and the 9-month change was +0.07 log units in placebo versus -0.02 log units in the active group. The between-group difference was not significant (z = -0.903, P = 0.376). Although placebo showed a small within-group improvement (P = 0.03), the active supplement did not show a meaningful benefit, and no adverse events were reported.

Study & population: Randomized controlled trial conducted in the United Kingdom among adults with age-related maculopathy or atrophic age-related macular degeneration.
Intervention: Participants in the active arm took 1 oral tablet daily with food for 9 months.
Key limitation: The active arm was small, with only 13 analyzed participants, and the trial had short follow-up of 9 months.

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Original abstract

No abstract is available for this paper.