Effect of Long-Term Consumption of Lactobacillus paracasei SD1 on Reducing Mutans streptococci and Caries Risk: A Randomized Placebo-Controlled Trial

Study answer

What this study found

Daily probiotic milk produced a beneficial oral effect overall. Salivary mutans streptococci were significantly lower in the probiotic group than in controls at T3 and T6 (P < 0.001 and P = 0.001), and in the probiotic group MS decreased during dosing and for 3 months afterward (T3-T9) compared with baseline (P < 0.001). The probiotic strain was detected in 85%, 80%, 60%, and 0% of participants at T3, T6, T9, and T12, suggesting temporary colonization. Caries progression was also lower with probiotic use, with DT increment at T12 of 0.30 ± 0.57 versus 0.57 ± 0.95 in controls overall, and…

Study & population

Randomized, double-blind, placebo-controlled trial in school-aged children in Thailand with generally good oral health.

Intervention

The active regimen was 5 g of reconstituted milk powder containing Lactobacillus paracasei SD1, mixed with 50 mL water and taken orally once daily for 6 months.

Key limitation

The active arm was small, and the study was conducted in a specific population of Thai school-aged children with generally good baseline oral health, which limits generalizability.

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Original abstract