Research paper
Effect of high-dose vitamin D supplementation on bone density in youth with osteogenesis imperfecta: A randomized controlled trial.
Citations: 29
Influential: 2
Interventional (Human) Studies
86
Study answer
What this study found
Higher-dose vitamin D increased serum 25-hydroxyvitamin D, but did not improve bone density, bone turnover, or muscle outcomes over 12 months. LS-aBMD z-score change was 0.0 in the 400 IU group versus 0.1 in the 2000 IU group (p=0.63), and radius trabecular vBMD z-score change was -1.0 versus -0.4 (p=0.22). Serum 25OHD increased more with 2000 IU/day than with 400 IU/day (30.5 vs 15.2, p=0.02), but mechanography, PTH, PINP, CTX, and fracture outcomes were not significantly different. Vitamin D3 at 2000 IU/day was reported as safe, with no hypercalcemia, no hypercalciuria, and no serious…
- Study & population
- Randomized controlled trial in children and adolescents with osteogenesis imperfecta aged 6 to 19 years, recruited at Shriners Hospital for Children in Montreal, Canada.
- Intervention
- Oral vitamin D3 was given for 12 months at either 400 IU/day or 2000 IU/day.
- Key limitation
- The study was limited by its 12-month duration and the lack of a meaningful effect on the primary skeletal outcome despite improved vitamin D status.
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