Research paper
Effect of dietary interventions in mild cognitive impairment: a systematic review
Study answer
What this study found
Vitamin E, Ginkgo biloba, and Souvenaid Fortasyn Connect did not reduce progression from MCI to dementia/AD. Some regimens improved memory and selective cognitive domains, notably B vitamins (folic acid, B12, B6), DHA/EPA, DHA, cocoa flavonols, concord grape juice, and wild blueberry juice, but results were inconsistent across studies due to heterogeneity and small sample sizes. Overall, dietary factors may have potential cognitive benefits in MCI, but robust, standardized RCTs are needed to confirm effects.
- Study & population
- Systematic review of randomized controlled trials in adults with mild cognitive impairment (MCI).
- Intervention
- Vitamin E: 2000 IU daily for 2 years (memory outcomes); 2000 IU daily for 3 years (progression to dementia/AD).
- Key limitation
- English-language searches with no grey literature; small number of randomized trials; substantial heterogeneity in interventions and cognitive outcomes; not meta-analysed; some trials underpowered; short study durations; variability in cognitive measures; risk of bias uncertain in several studies.
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Open PDFOriginal abstract
Abstract Diet has been investigated in relation to its ability to promote cognitive function. However, evidence is currently limited and has rarely been systematically reviewed, particularly in a mild cognitive impairment (MCI) population. This revie…