Effect of a Nutritional Support System to Increase Survival and Reduce Mortality in Patients with COVID-19 in Stage III and Comorbidities: A Blinded Randomized Controlled Clinical Trial

Study answer

What this study found

Adding NSS to standard care significantly improved outcomes. Day-40 survival was 97.5% in the IG vs 82.5% in the CG (mortality 2.5% vs 17.5%; p=0.027). Progression to mechanical ventilation occurred in 7.5% of IG vs 17.5% of CG (3/40 vs 7/40). Among those who progressed to MVA, survival was 66.7% in IG vs 28.6% in CG, with IG survivors on MVA for 11 days vs 26 days in CG. IG required less supplemental oxygen by day 3 (4.5 L vs 6 L; p=0.014) and showed greater improvement in qSOFA by day 3 (p=0.040). By day 40, SpO2 without supplemental oxygen was higher in IG (92.08% vs 90.39%; p=0.030).…

Study & population

Randomized, triple-blinded, controlled clinical trial conducted at Centro Medico ISSEMyM Toluca, Mexico.

Intervention

B-complex vitamins: Cyanocobalamin 10 mg, Thiamin 100 mg, Pyridoxine 100 mg; intramuscularly every 24 h for the first 5 days.

Key limitation

Small, single-center trial; 80 randomized with 33 CG and 39 IG completing 40-day follow-up; results may not generalize; replication in multicenter studies needed.

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Original abstract