Research paper
Early High-Dose Vitamin D3 for Critically Ill, Vitamin D-Deficient Patients.
Study answer
What this study found
Early high-dose enteral vitamin D3 did not improve survival or other major clinical outcomes in critically ill, vitamin D-deficient patients. Ninety-day mortality was 23.5% (125 of 531) with vitamin D3 versus 20.6% (109 of 528) with placebo, a difference of 2.9 percentage points (95% CI, -2.1 to 7.9; P = 0.26). In the screened-deficient population, 90-day mortality was also not significantly different: 23.3% (159 of 681) versus 20.9% (137 of 656), difference 2.5 percentage points (95% CI, -2.0 to 6.9; P = 0.28). Secondary outcomes, including mortality to day 28, hospital mortality to day 90,…
- Study & population
- Randomized, placebo-controlled trial in critically ill adults with vitamin D deficiency enrolled within 12 hours of the decision to admit to the ICU.
- Intervention
- A single enteral dose of vitamin D3 540,000 IU was given within 2 hours of randomization, administered orally or through a nasogastric or orogastric tube in liquid form.
- Key limitation
- The trial was stopped for futility, limiting the chance to detect smaller benefits.
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Open PDFOriginal abstract
BACKGROUND Vitamin D deficiency is a common, potentially reversible contributor to morbidity and mortality among critically ill patients. The potential benefits of vitamin D supplementation in acute critical illness require further study. METHODS We …