Research paper
Dopamine Precursor Depletion in Healthy Volunteers Impairs Processing of Duration but Not Temporal Order
Citations: 10
Influential: 0
Interventional (Human) Studies
86
Study answer
What this study found
APTD significantly impaired participants' ability to accurately reproduce interval durations, especially in the 1400 ms condition. No significant effects were noted for temporal order processing.
- Study & population
- Nineteen healthy volunteers underwent two sessions, one with APTD and one with a balanced amino acid drink.
- Intervention
- Acute phenylalanine/tyrosine depletion (APTD) used to lower dopamine precursor availability.
- Key limitation
- Small sample size; effects of APTD considered only in limited contexts of duration processing and not temporal order.
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Open PDFOriginal abstract
Abstract Studies in animals and humans have implicated the neurotransmitter dopamine in duration processing. However, very few studies have examined dopamine's involvement in other forms of temporal processing such as temporal order judgments. In a r…