Research paper

Dairy products, calcium and phosphorus intake, and the risk of prostate cancer: results of the French prospective SU.VI.MAX (Supplémentation en Vitamines et Minéraux Antioxydants) study

British Journal of Nutrition

Mar 2006

DOI: 10.1079/BJN20051670

Citations: 66

Influential: 3

Observational Studies (Human)

Study answer

What this study found

Dairy product and dietary calcium intakes were associated with higher prostate cancer risk. Dairy intake: highest quartile vs lowest 1st quartile RR 1.35 (1.02–1.78); calcium intake: highest quartile RR 2.43 (1.05–5.62); dairy calcium RR 2.94 (1.16–7.51). Yoghurt: 125 g/d increment RR 1.61 (1.07–2.43) independent of calcium; fresh cheese in upper tertile RR 2.13 (1.09–4.15). Milk or cheese alone showed no significant association. Calcium–phosphorus interaction observed; higher risk linked largely to calcium in dairy, though yoghurt may have another component contributing. Authors conclude…

Study & population: Population: Men aged 45-60 at baseline; cancer-free at start; 2776 analyzed; median follow-up 7.7 years.
Key limitation: Small number of cases (69); limited statistical power; strong correlation between calcium and phosphorus complicates disentangling independent effects; observational analysis within a trial; potential residual confounding; limited generalizability beyond French middle-aged men; dietary assessment relies on 24-h…

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