[Comparison between magnesium sulfate and dexmedetomidine in controlled hypotension during functional endoscopic sinus surgery].

Study answer

What this study found

Dexmedetomidine produced better controlled hypotension and a clearer surgical field than magnesium sulfate, with higher surgeon satisfaction. Blood loss scores favored dexmedetomidine, with more patients in the lowest bleeding categories and fewer in higher bleeding categories (p=0.002), and surgeon satisfaction was greater (p=0.001). Recovery to Aldrete score >= 9 was faster with dexmedetomidine (11.8 ± 2.5 min vs 14.8 ± 3.0 min; p=0.001). Dexmedetomidine also reduced the need for nitroglycerin (6.6% vs 33.3%; p=0.02), while anesthesia time, surgery time, extubation time, opening eyes,…

Study & population

Adult patients aged 18 to 65 years with ASA I-II status undergoing functional endoscopic sinus surgery were randomized 1:1 to dexmedetomidine or magnesium sulfate.

Intervention

This randomized comparison evaluated two active IV regimens during functional endoscopic sinus surgery.

Key limitation

The trial was small, with only 30 participants per active arm, limiting precision and generalizability.

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Original abstract