Cobalamin Intake and Related Biomarkers: Examining Associations With Mortality Risk Among Adults With Type 2 Diabetes in NHANES.

Study answer

What this study found

Serum cobalamin, dietary cobalamin intake, and cobalamin supplement use were not associated with reduced all-cause mortality in adults with type 2 diabetes, regardless of metformin use. Doubling methylmalonic acid (MMA) was associated with higher all-cause mortality (HR 1.31; 95% CI 1.18–1.45) and higher cardiac mortality (HR 1.38; 95% CI 1.14–1.67; P < 0.001). When categorized by MMA and B12, hazard ratios for all-cause mortality were 1.00 (reference), 0.98 (0.75–1.28), 1.49 (1.16–1.92), and 1.96 (1.38–2.78), respectively, with higher risk in the MMA-high/B12-high group and strongest in…

Study & population

Design: prospective cohort analysis of NHANES data.

Intervention

Self-reported use of cobalamin (Vitamin B12)–containing dietary supplements in the past 30 days; dosage and duration not reported.

Key limitation

Dietary cobalamin intake was estimated from 1–2 24-hour recalls, which may not reflect habitual intake.

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Original abstract