Clinical trial: a nutritional supplement Viusid, in combination with diet and exercise, in patients with nonalcoholic fatty liver disease

Study answer

What this study found

Viusid plus lifestyle modification produced greater histologic improvement than lifestyle change alone, especially for the nonalcoholic activity score and key steatosis-related features. NAS improved from 4.18 to 0.54 in the Viusid arm versus 4.45 to 2.2 in controls, with a between-group P value < 0.001; between-group differences also favored Viusid for steatosis (P < 0.001), ballooning (P = 0.002), and lobular inflammation (P = 0.025), while fibrosis was not significantly different (P = 0.07). ALT and AST improved in both groups without a significant between-group difference. Viusid also…

Study & population

Randomized 1:1 clinical trial in adults with histologically confirmed nonalcoholic fatty liver disease/steatohepatitis at the National Institute of Gastroenterology in Havana, Cuba.

Intervention

Viusid was given orally as three 50 g sachets daily for 24 weeks, alongside a hypocaloric diet and aerobic exercise.

Key limitation

This was a small, single-center trial with only 24 weeks of follow-up, which limits precision and long-term inference.

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Original abstract