Research paper
Clinical and Microbiological Effect of a Multispecies Probiotic Supplementation in Celiac Patients With Persistent IBS-type Symptoms
Study answer
What this study found
A 6-week multispecies probiotic improved IBS-type symptom severity versus placebo and was associated with microbiota changes, including an increase in bifidobacteria, with no adverse events reported. IBS-SSS fell from 295 ± 84.9 to 170.1 ± 53.4 in the probiotic arm, with a delta over baseline of -15.9% ± 14.8% (P = 0.008), and treatment success was higher than placebo in both ITT analysis (14.8% vs 3.6%, P < 0.04) and per protocol analysis (15.3% vs 3.8%, P < 0.04). GSRS also favored probiotics (12.2 ± 5.5 vs 16.7 ± 6.7 at end of treatment; P = 0.001), and Bristol Stool Charts improved (2.2…
- Study & population
- Adults with celiac disease who were adherent to a strict gluten-free diet and had persistent IBS-type symptoms were enrolled in an Italian randomized, placebo-controlled trial conducted at gastroenterology units in Bari, Castellana Grotte, Foggia, and Taranto from 2013 to 2015.
- Intervention
- A multispecies probiotic sachet was taken once daily for 6 weeks.
- Key limitation
- The trial was short, lasting only 6 weeks, and the active arm sample was modest.
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Open PDFOriginal abstract
Goals: The goals of this study were to evaluate the efficacy and safety of a probiotic mixture in patients with celiac disease (CD) with irritable bowel syndrome (IBS)-type symptoms despite a strict gluten-free diet (GFD). Background: About 30% of pa…