Cardioprotective Effect of Nigella sativa in Pediatric Patients with Type 1 Diabetes Mellitus: A Randomized Controlled Study

Study answer

What this study found

Nigella sativa seed oil appeared to improve subclinical left ventricular dysfunction and several cardiometabolic and inflammatory markers, while glycemic measures did not differ meaningfully. After 3 months, the active group showed better between-group values for cholesterol (153 ± 13.5 vs 163 ± 17.4; p = 0.024), LDL-C (78.9 ± 9.8 vs 89.4 ± 11.5; p < 0.001), MDA (3.8 ± 0.9 vs 4.74 ± 1.16; p < 0.001), nitric oxide (40.5 ± 3.7 vs 49 ± 4; p < 0.001), TNF-α (8.5 ± 2.4 vs 10.3 ± 2.9; p = 0.009), TGF-β (7.4 ± 2.5 vs 8.9 ± 2.94; p = 0.02), and troponin I (0.04 ± 0.02 vs 0.061 ± 0.02; p = 0.002).…

Study & population

Randomized controlled study in pediatric patients with type 1 diabetes mellitus from the pediatric endocrinology outpatient clinic of Tanta University hospitals in Egypt.

Intervention

Nigella sativa seed oil (Baraka; Pharco Pharmaceuticals, Cairo, Egypt) was given at 450 mg twice daily after meals for 3 months, added to insulin therapy.

Key limitation

The study was small, with only 30 participants per active arm, and was conducted at a single center.

View full study detailsView sourceOpen PDF

Original abstract