Calcium-vitamin D cosupplementation influences circulating inflammatory biomarkers and adipocytokines in vitamin D-insufficient diabetics: a randomized controlled clinical trial.

Study answer

What this study found

Overall, calcium and/or vitamin D supplementation improved inflammatory biomarkers, with the combined calcium-plus-vitamin D regimen showing the clearest benefit. IL-6 decreased in all active arms versus an increase in placebo (Calcium −2 Ϯ 1, Vitamin D −4 Ϯ 1, Ca+D −4 Ϯ 1, Placebo 3 Ϯ 1; P < .001), and TNF-α also fell significantly in adjusted models (Model 1 P = .04), although the effect was not significant after further adjustment (Model 2 P = .23). Leptin declined more in the active arms than placebo, while adiponectin changes were not significantly different after adjustment; hs-CRP did…

Study & population

Randomized controlled clinical trial with stratified block randomization in adults with type 2 diabetes and vitamin D insufficiency in Isfahan, Iran.

Intervention

Three oral active regimens were tested for 8 weeks: calcium carbonate 1000 mg/day, vitamin D3 50,000 IU/week, or the combination of calcium carbonate 1000 mg/day plus vitamin D3 50,000 IU/week.

Key limitation

Short 8-week duration and modest arm sizes limit certainty about durability and clinical relevance.

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Original abstract