Research paper
Calcium supplementation and bone mineral density in females from childhood to young adulthood: a randomized controlled trial.
The American journal of clinical nutrition
Q1
Citations: 209
Influential: 4
Interventional (Human) Studies
82
Study answer
What this study found
Calcium supplementation improved bone mass accrual during the pubertal growth spurt, with some benefits persisting into young adulthood. At 4 years, the supplemented group had significantly higher total-body BMD, proximal and distal radius BMD, and metacarpal cortical area to total area ratio after covariate adjustment, including total-body BMD P = 0.0003 for covariate-adjusted values and P = 0.0006 for gain, distal radius BMD P = 0.0026, and CA:TA P = 0.024. In the 7-year cohort, mean responses remained significant for total-body BMD P = 0.0004, proximal radius BMD P = 0.024, and distal…
- Study & population
- Randomized controlled trial in 354 healthy White girls enrolled at pubertal stage 2 in central Ohio, with 1:1 allocation to calcium citrate-malate or placebo.
- Intervention
- Oral calcium citrate-malate supplementation at 1000 mg/day, given as 4 pills daily (2 in the morning and 2 in the evening), was compared with placebo.
- Key limitation
- Follow-up attrition was substantial, with only 51% completing the 7-year trial.
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