Calcium and Vitamin D Supplementation for Prevention of Preeclampsia: A Systematic Review and Network Meta-Analysis

Study answer

What this study found

Overall, calcium supplementation reduced preeclampsia risk and vitamin D also showed a possible benefit, although the vitamin D evidence was less certain. In direct meta-analysis, preeclampsia risk was lower with calcium versus placebo (RR 0.54, 95% CI 0.41 to 0.70), vitamin D versus placebo (RR 0.47, 95% CI 0.24 to 0.89), and calcium plus vitamin D versus placebo (RR 0.50, 95% CI 0.32 to 0.78). Network meta-analysis showed a similar pattern for calcium (RR 0.49, 95% CI 0.35 to 0.69), while vitamin D (RR 0.43, 95% CI 0.17 to 1.11) and calcium plus vitamin D (RR 0.57, 95% CI 0.30 to 1.10)…

Study & population

Systematic review and network meta-analysis of randomized controlled trials in pregnant women, including both low-risk and high-risk pregnancies from multiple countries.

Intervention

This systematic review evaluated calcium supplementation, vitamin D supplementation, and calcium plus vitamin D during pregnancy, each compared with placebo or control.

Key limitation

The vitamin D and calcium plus vitamin D estimates were based on few trials and were less precise than calcium alone.

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Original abstract