Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension.

Study answer

What this study found

Coenzyme Q10 did not produce a clinically significant reduction in blood pressure. For clinic measurements at end of treatment, the pooled effect was SBP MD -3.7 mm Hg (-8.9 to 1.5) and DBP MD -2.0 mm Hg (-4.8 to 0.8); 24-hour ambulatory BP also showed no effect (SBP MD -0.40 [-5.30, 4.50]; DBP MD -0.50 [-3.83, 2.83]). A reduction in clinic heart rate was reported in one trial (MD -4.80 [-9.31, -0.29]), but this was not corroborated by other measures. CoQ10 appeared well tolerated, with no significant adverse effects reported.

Study & population

Systematic review/meta-analysis of randomized trials in adults with essential hypertension, including one study in patients with metabolic syndrome and one study that allowed type 2 diabetes-related entry criteria.

Intervention

Oral coenzyme Q10 was evaluated as monotherapy added to usual care in adults with hypertension.

Key limitation

The evidence base was small, with only a few trials and limited total sample size.

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Original abstract