Baseline Serum 25-Hydroxy Vitamin D Is Predictive of Future Glycemic Status and Insulin Resistance

Study answer

What this study found

Baseline 25(OH)D was inversely associated with 10-year increases in fasting glucose, 2-h glucose, fasting insulin, HOMA-IR, and metabolic syndrome risk z score after adjustment for age, sex, smoking, BMI, season, and baseline outcome. Per 25 nmol/L increase in baseline 25(OH)D, fasting glucose decreased by 0.05 mmol/L; 2-h glucose decreased by 0.25 mmol/L; fasting insulin decreased by 4.2 pmol/L; HOMA-IR decreased by 0.16; metabolic syndrome risk z score decreased by 0.05. Associations persisted after further adjustment for IGF-1, PTH, calcium, physical activity, and social class.…

Study & population

Population-based prospective cohort (Ely Study, Cambridgeshire, UK).

Key limitation

Modest size; complete-case analysis included about 50% of the initial cohort; potential healthy participant bias; insufficient power to assess diabetes incidence; no data on sun exposure or vitamin D supplement use or repeated vitamin D measures; single geographic population (European Caucasians) limits…

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Original abstract