Research paper
Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults.
Study answer
What this study found
Higher urinary BPA concentrations were associated with higher odds of cardiovascular disease (OR per 1-SD increase in BPA, 1.39; 95% CI 1.18–1.63; P=0.001) and diabetes (OR per 1-SD increase, 1.39; 95% CI 1.21–1.60; P<0.001) after full adjustment. Higher BPA concentrations were also linked to clinically abnormal liver enzymes: GGT (OR per 1-SD increase, 1.29; 95% CI 1.14–1.46; P<0.001) and alkaline phosphatase (OR per 1-SD increase, 1.48; 95% CI 1.18–1.85; P=0.002). Associations persisted across alternative exposure metrics; in some analyses, highest BPA concentration quartile showed…
- Study & population
- Cross-sectional NHANES 2003–2004 analysis of associations between urinary BPA concentrations and health status in the U.S.
- Key limitation
- Cross-sectional design prevents causal inference; single-spot urinary BPA measurement may not reflect long-term exposure due to temporal variability.
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Open PDFOriginal abstract
CONTEXT Bisphenol A (BPA) is widely used in epoxy resins lining food and beverage containers. Evidence of effects in animals has generated concern over low-level chronic exposures in humans. OBJECTIVE To examine associations between urinary BPA conce…