Association Between Vitamin D Level and Clinical Outcomes of Assisted Reproductive Treatment: A Systematic Review and Dose-Response Meta-Analysis

Study answer

What this study found

Overall, higher vitamin D status was associated with better assisted reproductive outcomes, especially clinical pregnancy and live birth. Deficient vitamin D versus non-deficient status was associated with lower clinical pregnancy rate (OR 0.81, 95% CI 0.70–0.95, P = 0.01) and live birth rate (OR 0.69, 95% CI 0.54–0.89, P = 0.003). Deficient plus insufficient vitamin D versus sufficient vitamin D was also associated with lower clinical pregnancy rate (OR 0.71, 95% CI 0.55–0.91, P = 0.007) and live birth rate (OR 0.69, 95% CI 0.54–0.89, P = 0.003). Biochemical pregnancy, ongoing pregnancy,…

Study & population

Systematic review and dose-response meta-analysis of women undergoing assisted reproductive treatment, including IVF and ICSI, with vitamin D measured in serum or follicular fluid.

Intervention

Vitamin D exposure was evaluated as serum or follicular fluid vitamin D status in women undergoing assisted reproductive treatment, categorized across included studies as deficient, insufficient, and sufficient.

Key limitation

The evidence is based on observational studies rather than randomized trials, so confounding and reverse causation remain possible.

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Original abstract