Antioxidant and Anti-Inflammatory Properties of Hydroxyl Safflower Yellow a in Diabetic Nephropathy: A Meta-Analysis of Randomized Controlled Trials

Study answer

What this study found

HSYA showed overall benefit for diabetic nephropathy, with improvements in glycemic control, insulin resistance, lipids, inflammation, and oxidative stress, alongside better renal function indices. Pooled effects favored HSYA for FBG (SMD = -0.63, 95% CI -1.05 to -0.21), PBG (SMD = -0.51, 95% CI -0.98 to -0.03), HOMA-IR (SMD = -1.35, 95% CI -2.06 to -0.65), TC (SMD = -1.03, 95% CI -1.25 to -0.80), TG (SMD = -1.05, 95% CI -1.28 to -0.82), hsCRP (SMD = -1.96, 95% CI -2.55 to -1.38), IL-6 (SMD = -1.94, 95% CI -2.79 to -1.10), TNF-α (SMD = -1.32, 95% CI -1.96 to -0.67), MDA (SMD = -1.63, 95% CI…

Study & population

Systematic review and meta-analysis of 31 randomized controlled trial groups involving 2487 participants with diabetic nephropathy.

Intervention

Hydroxyl safflower yellow A (HSYA) was given intravenously, typically as an add-on to conventional therapy.

Key limitation

Evidence is limited by low study quality, small sample sizes, and substantial heterogeneity across outcomes, with I2 values often above 85%.

View full study detailsView sourceOpen PDF

Original abstract