Anti-inflammatory and antioxidant effects of resveratrol in healthy smokers a randomized, double-blind, placebo-controlled, cross-over trial.

Study answer

What this study found

Resveratrol showed a favorable anti-inflammatory and antioxidant effect in healthy smokers. Compared with placebo, end-of-resveratrol values were lower for CRP, with an adjusted ratio of 0.47 (95% CI 0.38-0.59), and triglycerides, with an adjusted ratio of 0.71 (95% CI 0.65-0.78). Total antioxidant status increased by 74.2 mol/L (95% CI 60.8-87.6), and no adverse events were reported. The findings suggest resveratrol may help reduce cardiovascular risk markers in this population.

Study & population

Randomized, double-blind, placebo-controlled, crossover trial in 50 healthy adult smokers aged 20-50 years without major chronic disease.

Intervention

Transmax resveratrol 500 mg was taken orally as one tablet each morning after an overnight fast for 30 days.

Key limitation

The trial was small and short, with only 30 days of active supplementation per period and one dropout in the resveratrol-first arm.

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Original abstract