Research paper
Administration of a dietary supplement ( N-oleyl-phosphatidylethanolamine and epigallocatechin-3-gallate formula) enhances compliance with diet in healthy overweight subjects: a randomized controlled trial.
Study answer
What this study found
The NOPE-EGCG formula improved adherence to the prescribed diet and several related outcomes versus placebo, but it did not produce significantly greater weight loss over 8 weeks. Compliance with the diet was achieved by 67 (94%) in the NOPE-EGCG group versus 49 (73%) in placebo (P=0.001), and dropout was 6% versus 27% (P=0.001). The supplement also improved insulin resistance (P<0.001), fullness/satiety (P=0.05), depressive symptoms on the Beck Inventory Scale (mean change -4.21 vs -1.36; treatment effect -2.85, 95% CI -4.78 to 0.91; P=0.005), and binge eating severity on the Binge Eating…
- Study & population
- Randomized controlled trial in healthy overweight adults of both sexes in Italy.
- Intervention
- The active supplement was PhosphoLEANe, taken orally as one capsule twice daily before lunch and dinner for 8 weeks, alongside a prescribed low-energy diet.
- Key limitation
- The intervention was tested over only 8 weeks, so durability of effects and longer-term weight outcomes remain uncertain.
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Open PDFOriginal abstract
Many studies have found that N-oleyl-ethanolamine (NOE), a metabolite of N-oleyl-phosphatidylethanolamine (NOPE), and epigallocatechin-3-gallate (EGCG) inhibit food intake. The main aim of this study was to evaluate the efficacy of 2 months of admini…