Research paper

A randomized trial to investigate the effects of pre-natal and infant nutritional supplementation on infant immune development in rural Gambia: the ENID trial: Early Nutrition and Immune Development

BMC Pregnancy and Childbirth

Oct 2012

DOI: 10.1186/1471-2393-12-107

Citations: 82

Influential: 3

Interventional (Human) Studies

Study answer

What this study found

No efficacy results are reported in this paper; it describes the ENID trial design and intended outcomes. The study was designed to test whether prenatal and infant nutritional supplementation could improve infant immune development, especially thymic development measured by thymic index at weeks 1, 8, 24, and 52 and antibody responses to vaccination. If benefit is shown, the trial is intended to identify the most effective supplement formulation and the most important timing of exposure during pregnancy or infancy.

Study & population: ENID was a randomized factorial trial in pregnant women in rural West Kiang, The Gambia, enrolled before 20 weeks gestation, and followed with their infants through the first year of life.
Intervention: This randomized factorial trial tested several oral nutritional regimens.
Key limitation: This source is a trial design paper rather than a results report, so no treatment effect can be assessed.

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Original abstract

No abstract is available for this paper.