Research paper
A randomized controlled trial of antioxidant supplementation for pain relief in patients with chronic pancreatitis.
Gastroenterology
Q1
Citations: 253
Influential: 13
Interventional (Human) Studies
92
Study answer
What this study found
Daily antioxidant supplementation reduced pain and improved oxidative stress markers versus placebo over 6 months. Painful days per month fell from 9.14 Ϯ 7.60 to 1.68 Ϯ 2.80 in the antioxidant group versus 7.21 Ϯ 5.34 to 3.36 Ϯ 4.35 with placebo; the reduction was 7.37 Ϯ 6.75 versus 3.21 Ϯ 3.99, with a mean difference of 4.15 (2.07, 6.23; P < .001). One third (23/71) of patients in the antioxidant group became pain free. Oxidative stress and antioxidant status also improved, including lower TBARS at 6 months (3.61 Ϯ 2.37 vs 5.43 Ϯ 2.69; P = .001) and higher vitamin A, vitamin C, vitamin E,…
- Study & population
- Randomized controlled trial in patients with chronic pancreatitis and significant abdominal pain treated at a tertiary care academic center.
- Intervention
- Daily oral antioxidant capsules were given for 6 months and matched to placebo capsules in appearance.
- Key limitation
- The trial was single-center with a relatively small sample and substantial attrition at 6 months, especially for biomarker analyses.
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